The eldest child of renowned scientist Franklin Storm, Sue Storm inherited her father's genius at an early age. Since early childhood, she has been one of the prodigies studying and working at the Baxter Building, a midtown Manhattan government research lab. Following her father into physics, at age eight she built a sugar-power rocket and accidentally destroyed her father's car, after which she changed her focus to "inner space" biology. Romancing brilliant Baxter Building classmate Reed Richards, Sue became formidable scientist in her own right, earning four doctorates in bio-chemical sciences. Attending the Nevada desert testing of Reed's N-Zone dimensional teleporter, Sue was transported a mere three miles into the desert by the device's malfunction. She was discovered by former Baxter Building instructor Dr. Arthur Molekevic, who took her to his underground facilities below Manhattan calmed her, and helped her gain control of her new abilities, while he sent a "monster" to the Baxter Building to retrieve the other three who had also been transformed by the N-Zone experiment. In the company of those three, Susan fled Molekevic and used her invisible protective force field to take them back to the surface.

Making the study of herself and her three partners her new life's work, Sue spent months investigating their abilities and charting their powers while improving her own understanding of herself. She has deduced the nature both Reed and Johnny's changes, though her own powers remain unexplained and she is unable to penetrate Ben's skin with any more detail than determining his internal fluid pressure. Sue continues to develop her force fields, though there are physical side effects to extreme usage. When Van Damme attacked the Baxter Building with a squad of flying insects, Susan contained a squad of them with a force field, developing a nosebleed in doing so, and later caught a crashing helicopter in her force field, suffering severe physical stress.

Susan has proven capable of standing her own, and after the team went public, she assumed the codename "Invisible Woman." Her force fields have been the Four's ace in the hole, saving their lives when Nihil dumped Reed and Ben into the near-vacuum of the N-Zone and single-handedly stopping the time-traveling Chrono-Bandits. She co-created the chrono-tunnel with Reed, and has conducted biological studies of the Kree alien Mahr Vehl and extra-dimensional life in the N-Zone.

Though her new found fame has brought her unsought attention from the likes of billionaire playboy Tony Stark and the Atlantian criminal Namor, she remains romantically attached to Reed despite her concerns about his over devotion to science.