Ben Parker of this alternate universe, Earth-6078, was not killed by a robber as did his counterpart on Earth-616. Thus his nephew, Peter Parker, was not inspired by his death to use his powers as Spider-Man to fight crime. Ben became a widower when his wife May fell down a staircase and died.

After May's death, Peter revealed his powers to Ben and became the professional wrestler/television star known as “Spider-Man,” with Ben receiving a 20% commission as his agent; but as Spider-Man’s fame and wealth increased, his relationship with his Uncle Ben deteriorated. This distanced the two of them to the point that they no longer met each other in person.

Practically deserted by Peter, a lonely and desperate Ben accepted an offer from the villainous Robin Borne, Hobgoblin of Earth-9500’s 2211 AD, to see his wife and nephew, unaware that the multiverse-traversing Hobgoblin was actually transporting him to reality-616, where Ben died instead of May and Spider-Man became a super-hero rather than a self-centered celebrity. Ben returned to what he believed to be his Forest Hills home only to find it has been burned down and soon discovered his wife was still alive. May was horrified to see her supposedly deceased husband confront her. Ben fought with the Avenger's butler, Jarvis (dating May at the time) after being mistaken for an imposter.

The Hobgoblin of 2211 soon explained to Ben that he had been taken to another reality, but got into a fight with Spider-Man before she could explain more.

Lacking purpose in this new world, Ben Parker stumbled into a alleyway were the Chameleon of 2211 killed him and took his form. The Sandman's father, Floyd Baker, was mistakenly accused of murdering Ben.