An experiment of the clandestine organization They (a.k.a. the Third Person or the unseen face that controlled mankind), the woman known only as the Lynx was born without an immune system and raised in a germ-free environment without human contact. As a result, They’s chief scientist, German geneticist Doctor Reigert Ilves, believed the girl to be a perfect subject for his experiments with the drug Panacea, capable of curing all known diseases, and he injected her with the only existing sample. Guilt-stricken over this, Ilves sought to destroy his work by setting his laboratory on fire. The mutant hero Wolverine arrived on the scene, investigating rumors of Ilves’ experiment, but was too late to save Ilves. The Lynx escaped, but Wolverine soon tracked her down and, after a brief scuffle, they were both incapacitated by Courier (Hans Mittlesteadt), a mutant operative of the German government, who were seeking to reclaim the Panacea. While a recovered Wolverine battled Courier, the French mercenary Le Peregrine abducted the Lynx for his employer, corrupt billionaire Imus Champion, who sought the Panacea to cure a rare disease that was killing him.
Le Peregrine delivered the Lynx to Champion’s Southern California base, whereupon Champion sent the monstrous Fleshtones to kill Le Peregrine in order to keep the Lynx’s location a secret. Le Peregrine defeated them with the aid of Wolverine & Courier (who had tracked him to Champion’s base) and the Black Widow (Natasha Romanova), an official representative of S.H.I.E.L.D. tasked with bringing in the Lynx. The quartet eventually agreed to work together to free the Lynx, after which the Black Widow convinced the others to take the Lynx into S.H.I.E.L.D.’s protective custody. Wolverine and Courier suspected that S.H.I.E.L.D. might experiment on the Lynx, though, so they liberated her. Wolverine took her to a S.H.I.E.L.D. safehouse, where he soon realized that S.H.I.E.L.D. had injected the Lynx with a persona-inducing serum once used by the Black Widow, hoping that a personality would help her articulate her memories. Ultimately, he allowed the Lynx to revert to her feral state, and she accompanied Wolverine and the Black Widow to the Antarctic base of They, where they discovered the Malaigent, the world’s deadliest disease, which also acted as an “antidote” for the total immunity of the Panacea. After Champion and his forces attacked They’s base, the Lynx and her newfound allies were rejoined by Courier and Le Peregrine in defeating the forces of They and Champion. The Lynx then consumed the Malaigent, which seemingly neutralized the Panacea in her system.
Wolverine released the Lynx in a remote part of the Canadian wilderness and departed, hoping that she would live out her life in peaceful solitude, though the smitten Lynx mistakenly believed Wolverine would return to live with her as her mate.