The Man-Beast is the most powerful, and most evil of the New Men, animals evolved by the High Evolutionary
into human-like intellects and forms. Following many successes, the High Evolutionary sought a warrior race to defend his Citadel of Science on Mount Wundagore should mankind lapse into another world war. The Evolutionary developed Isotope C, which could endow new Knights of Wundagore with greater strengths. Isotope C was tested on the first wolf, which the Evolutionary had evolved, but an unexpected visit from the Norse god Thor distracted him, and the creature was left under the Genetic Accelerator too long, evolving the creature to the end point of human and lupine evolution. Hating all life, this Man-Beast attacked Thor and the Evolutionary, then used the Genetic Accelerator to form its own New Men army.