As the queen of the Inhuman royal family, Medusa spends much of her time fighting for the right of the genetically-altered Inhuman race to exist. She stands against anyone who opposes her people, from humanity to the Kree, to other members of the royal family, like Maximus, the brother of her husband and Inhuman king Black Bolt.
With her mane of deadly red locks, Medusa commands respect. And, as Black Bolt does not speak for fear of the destructive power his voice wields, one of Medusa's main roles as queen-consort is to interpret his wishes and communicate them to their subjects.
Medusa was born into the royal family of the Inhumans, and so raised as an elite, meant to be queen. However, Medusa rebelled against her strict upbringing. Though she was betrothed to Black Bolt at a young age, she flirted briefly with his younger brother, Maximus - a flirtation made easier by the fact that Black Bolt was kept in quarantined isolation for many years.
Medusa began to correspond electronically with Black Bolt in his isolation and the two bonded, developing a personal sign language for communication that only they understood. She learned to interpret Black Bolt's body language and fell in love with him. After his release and the tragic death of Black Bolt's parents, Medusa grew even closer to him.