Not much is known regarding the man known only as the Misfit. He apparently underwent treatment by the Power Broker, a man profiting by endowing others with superhuman abilities, hoping to increase his strength. However, although the treatment was effective, it grotesquely distorted his body. About the same time, the criminals known as the Night Shift, led by the vigilante called the Shroud, attacked the Power Broker, thereby aiding the hero Captain America in exposing the criminal. The team encountered the Misfit in doing so, and he elected to join the team.
The Misfit participated in the group's subsequent activities, including an attack on the Avengers' West Coast branch in revenge for capturing the Night Shift member, Digger. Eventually, the Night Shift mutinied against the Shroud's leadership, and presumably the team continued its villainous activities. Because of their frequent battles with the Avengers, he has developed an special enmity for U.S.Agent.