Of Vietnamese descent, Quicksand was once a scientist working at a nuclear facility when an accident transformed her body into a sand-like substance. Petty and selfish, she had a hard time adjusting to her transformation. She called herself Quicksand and attacked the nuclear reactor in rage and in hopes of revenge, hoping to force it to shut down. She was confronted by Thor but nonetheless succeeded in causing the reactor to meltdown. Thor prevented disaster by using his hammer to transport the entire facility to another dimension, and Quicksand escaped.
She was later contacted by Mongoose, on behalf of Tagar, who desired a cell sample from Thor in order to create a race of gods. She wanted nothing to do with Thor but was persuaded to battle him once Mongoose showed her a device that supposedly would transform her back to normal. Quicksand barely managed to hold her own against Thor, and once Mongoose collected the tissue sample, she escaped once more.
Since then, Quicksand had apparently resigned herself to her transformation, and even, in fact, to revel in the power and profit she has enjoyed as a super-criminal. She served for a time with Superia's Femizons until the organization was shut down by Captain America and Paladin. Later, she somehow came to the attention of the rogue Egyptian god Seth, who dispatched her, Bison, and Mongoose to steal a sample of Inferno-42 from the intelligence agency S.H.I.E.L.D.. In the course of this mission, they battled Thunderstrike, SHIELD agent Alex DePaul, and hero-for-hire Luke Cage. During the battle, a conscience-stricken Bison turned on his partners, defeating Quicksand and saving the life of DePaul, who let Bison go free in gratitude.
At some point, she was invited to join the Crimson Cowl's Masters of Evil, and she accepted, hoping to get rich through the Masters' blackmail scheme using global weather control. The team was defeated and apprehended by the Thunderbolts, and Quicksand was among those remanded to custody.