Rogue's parents died in the early days of the Human-Mutant War. Rogue was placed in a human orphanage until it was discovered she was actually a mutant.
Upon discovering her mutant abilities, the government sent two S.H.I.E.L.D. Agents, Mystique and Madame Web, S.H.I.E.L.D.'s resident telepath, to the orphanage. They were able to convince the girl to come with them to S.H.I.E.L.D. and to train as an agent. With her unique mutant abilities, it was obvious to S.H.I.E.L.D. Director Sebastian Shaw that Rogue would be a perfect agent. During her training, Rogue was adopted by Mystique and the two have a very strong bond.