To Squash a Spider
Spider-Man has yet to attract a sizable Rogues Gallery, but his first real Super Villain adversary is Adrian Toomes, the Vulture.
Over the course of Spider-Man’s interactions with the Vulture, he advanced from a nuisance in Toomes’ eyes to a true obstruction in the man’s schemes. Toomes also perhaps saw a bit of himself in Spider-Man, albeit at a younger age. Unfortunately, the Vulture discovered his foe’s secret identity and was able to initially warn Parker off with threats toward his family and friends. But, the young man’s sense of responsibility and justice outweighed any fear and he did everything within his power to ensure that Toomes never flew again. Now in prison, the Vulture still harbors Spider-Man’s secret, though he had decided to keep that to himself as an apparent sign of respect towards his enemy.
In addition to the Vulture himself, two of his associates may also still cause trouble for Spider-Man: Herman Schultz, AKA the Shocker, who wields a powerful gauntlet inherited from his late colleague, Jackson Brice, and Mac Gargan, a dangerous criminal who was injured in a confrontation with Spider-Man. Both men have been incarcerated, but Gargan in particular seems eager to enact his revenge on New York’s young champion.
When Thanos made his play for the Infinity Stones, Spider-Man, coming to Iron Man’s aid, placed himself in direct opposition to both Thanos and those who serve him.
Classmates, Comrades, and Kin
May Parker took her nephew in to raise him as if he was her own son and has instilled values in Peter Parker that serve him well. So close are the two that he worries over hurting May with his Spider-Man activities and feels the pain of lying to her. May is easygoing to some extent, but is quick to let her nephew know when she is unhappy with any situation he may be involved in.
As a student at the Midtown School of Science and Technology, Parker enjoys only a very small circle of friends, partially due to his extracurricular time as Spider-Man. His best friend is his classmate Ned, who discovers Spider-Man’s secret identity by accident and is in complete awe over the details of Parker’s costumed career. During Spider-Man’s first real adventure involving a major adversary, Ned provides valuable support, despite his seemingly bumbling demeanor.