Always accompanied by the deadly twin warriors Thais and Thaiis, Vargas claimed that mutants are deviations from the norm, an evolutionary dead end nature explored until it found the true path for the next step in mutant kinds development, the legitimate Homo Sapiens Superior - Vargas. Believing mutants are obsolete and must make way for Earth's true inheritors, Vargas seemed determined to remove them personally, one at a time. Learning the X-Men were in Spain seeking Destiny's prophetic diaries, Vargas sought the diaries for himself. During a hostile confrontation with Rogue, Psylocke, and the Beast in the Spanish Action Forces's base, Vargas informed them he had only come for one of them. Accepting a challenge from Psylocke, he slew her with ease, saying she was the first but not the last. Soon after, having located the diary, Vargas stole it from Destiny's house. When Gambit subsequently broke into Vargas' home, Vargas spared his life on a whim. Disturbed to read in the diary that Rogue would slay him, Vargas resolved to deny this destiny and faced her in Madripoor. Initially Vargas had the upper hand, but Rogue gradually absorbed his abilities each time he struck her until she was his equal, his superior considering her other powers. Poised to slay Vargas, Rogue hesitated, unsure she wished to be bound by the future Destiny had foretold. Rogue Spared Vargas in order to break the future the diaries had fortold, thus illegitamizing them.
Vargas was murdered by the Sinisters Marauders just before Messiah Complex as part of his attempt to prevent anyone from himself predicting the birth of Hope.