Zodiac appeared after Norman Osborn
temporarily gained control of S.H.I.E.L.D.
, claiming to have killed the entire Zodiac organization
to earn his moniker. Enlisting Death Reaper
, Manslaughter Marsdale
and the Clown
into his gang, Zodiac waged war against Osborn, feeling Osborn's rise to power insulted him as a villain. Using his team as a major distraction, Zodiac obtained his true goal – the Zodiac Key
! Killing several H.A.M.M.E.R. agents, severely wounding the Human Torch
coupled with murdering hundreds when he blew up the hospital Torch was in, unleashing Red Ronin upon the citizens of New York and assassinating the only person close to uncovering his plans, Zodiac quickly shot up to number one on Osborn's hit list; even if Osborn didn't know exactly who he was looking for.