Big changes are happening for the Amazing Spider-Man: Bigger threats, bigger guest-stars, and a big opportunity that could turn Peter Parker's life around! Which cast members are staying and who's saying goodbye? Find out as we're introduced to new characters and reintroduced to a number of Spidey villains as they make the triumphant return to the book! Plus: New developments for Mayor J. Jonah Jameson, the staff at Front Line, and The Sinister Six! Collecting AMAZING SPIDER-MAN #648-651.