Mister Sinister

Marvel’s resident expert geneticist. Dr. Nathaniel Essex’s long history of experimenting on mutants is as horrifying as his origin and self-made mutations. In his quest for a perfect mutant race, Essex procures his subjects by any means, earning him a name as evil as his intent - Mister Sinister.

Unnatural Selections

Something Sinister This Way Comes

in Uncanny X-Men (1963) #221

In his first appearance, Sinister recruits his mutant Marauders to eliminate Madelyne Pryor – his very own clone of Jean Grey.

A History of Violence

in X-Men: Colossus Bloodline (2005) #3

Chronicling the unexplored past of Nathaniel Essex. In Victorian London, a young biologist becomes inspired by Darwinian theory…and adapts his own scientific method for the Origin of a Super Species.


in Uncanny X-Men (1963) #239

In Inferno, Sinister’s strange fixation with Cyclops leads to the creation of his perfect mutant. Nathan Summers is born of Scott and Jean Grey’s clone in a carefully controlled environment. But when Madelyne’s dark nature manifests itself in the Goblin Queen, Essex’s happy family becomes another failed experiment.

The Nasty Boys

in X-Factor (1986) #75

Sinister’s task force makes their first appearance while fighting X-Factor – and show off their barrage of weird mutant powers!

Morlock Massacre

in Uncanny X-Men (1963) #350

In an attempt to cleanse the mutant race, Essex once employed a team of ‘Marauders’ to kill the Morlocks, a sewer-dwelling community of mutants. Gambit’s involvement in the Massacre is laid bare, as is his complicated past with Sinister.

Nathan Summers

in Cable (1993) #6

Sinister displays his strength and telekinesis while teaching Cable a lesson about his parentage. He also reanimates Cable’s evil clone Stryfe, placing his consciousness inside Nathan’s body.

The Marauders

in X-Men (2004) #203

Gambit, Mystique and Lady Mastermind join the Marauders in Sinister’s bid to save mutantkind from extinction.

Messiah Complex

in X-Factor (2005) #27

Sinister’s dangerous obsession with mutants seals his doom. In what could be mutants’ final hour, Sinister and his team rush to claim the mutant baby known as the Messiah. But the madman oversteps his bounds, underestimating the ruthlessness of the cohorts he keeps.


in Uncanny X-Men (2011) #1

In one of his more baffling turns, Sinister creates a Utopian haven. And for Essex, ‘Utopia’ is Victorian England with a population of Sinister carbon copies!