A shadowy program tests radical new technologies on the Moon! The test goes wildly awry, killing all but four of the young test subjects, wiping out the secret lunar base, and blasting a billiond of tons of the moon's mass into orbit! Now, gifted with rality-distorting "meta-talents," all four of the surviving test subjects fight invading anomalies as the Megascale Metatalent Response Team Fantastic Four! But the massive burst of energy that gave them their fabulous powers has drawn the attention of various entities from across the galaxy (and perhaps even from other realities)! And these strange beings have dispatched forces to investigate humanity's use of potentially lethal new technologies - including the awesome Annihilus!