What happens when we take Squirrel Girl back to her roots? Well, we shoot her into space, OBVIOUSLY. Nancy and Tippy find themselves on an alien world where all is not what it seems. Squirrel Girl needs to find a way to get to the other side of the universe to save 'em, STAT. Intergalactic transport through the cosmic realm? This sounds like a job for the Sorcerer Supreme! I'm sure Doctor Strange will be happy to he - I'm sorry, what's that? Doctor Strange is gone and now LOKI is Earth's Sorcerer Supreme? Oh. Well, I'm sure he'll do his best. After all, what could possibly go wrong? Guess what, in this issue, everything possible goes wrong!