Not much is known about this version of the Zodiac organization. This cartel seemed based on pursuing personal wealth through performing mercenary actions and acts of terrorism. Their leader, another man calling himself Scorpio, wielded a weapon reminiscent of the original Zodiac Key, but its origins remain unrevealed as well. Scorpio and his team were guided by the old woman known only as Ecliptic, who had the ability to foretell the future.
In the Zodiac's first known mission, they were hired by the Canadian government's Department H to fight the latest incarnation of their sponsored team, Alpha Flight. In doing so, Scorpio led the group in framing a militant special interest group. Alpha Flight discovered the truth and confronted the Zodiac. During the battle, the Zodiac's Virgo disappeared while fighting the Flight's Murmur. Enraged, Scorpio ordered he team to kidnap the Flight's Madison Jeffries before escaping, and he also proceeded to sever ties with Clarke, his contact with the Canadian government. The Zodiac only returned to Department H in order to steal the powerful the Nth Projector, a device capable of allowing interdimensional travel, although the device was stolen from the Zodiac in turn by Imus Champion.
This version of the Zodiac was later confronted by the mercenary team Weapon X, who was intent on recruiting Madison Jeffries for themselves. Jeffries had in the meantime been brainwashed into serving the Zodiac as their version of Gemini. The members of Weapon X kidnapped Jeffries, killing the other members of the Zodiac.