Young mutant shape-shifter Vanessa Carlysle fell into a life of prostitution in Boston where she met and fell in love with mercenary Wade Wilson. Carlysle was soon saved from Wilson’s vengeful employers by Zoe Culloden, a time-traveling agent of Landau, Luckman & Lake who had journeyed into the past to prevent Wilson’s eventual self-destruction. That night, Wilson broke up with Carlysle after learning he had cancer, leaving her heartbroken. Carlysle became a mercenary herself, eventually employed by arms dealer Tolliver, who had her impersonate the mercenary Domino so as to spy on Cable, even joining Cable’s new X-Force strike team. Tolliver ultimately ordered Carlysle to bomb X-Force’s headquarters, but she had come to care for her teammates, and she stalled until Tolliver dispatched the masked mercenary Deadpool (Wilson) to force her hand. Confronted by X-Force over her betrayal, but still posing as Domino, Carlysle helped them fight Tolliver. While Cable discovered the true Domino still alive as Tolliver’s prisoner, Deadpool felled Carlysle, who escaped.
Carlysle went into hiding, but was found by first Deadpool and then Domino. Carlysle delayed Domino’s intended retribution by helping her locate X-Force, after which she escaped again. Carlysle then became involved in the hunt for Tolliver’s will, during which she was mortally wounded by Slayback but survived by copying Deadpool’s healing factor. Later, Carlysle sought to live a peaceful life in San Francisco with Garrison Kane, but she soon encountered Deadpool again. Carlysle was subsequently captured by the emotion-manipulating Psycho-Man, who sought Kane’s advanced technology, but was rescued from the Microverse by Kane, Cable, Domino and the Microverse’s resident heroes, the Microns. Returning to Earth, Carlysle finally made peace with Domino.
Seeking revenge on Deadpool, Taskmaster and the Wizard hired Carlysle to impersonate the super-strong Titania and gain Deadpool’s trust, though he later confessed he had seen through her disguise. She went on to join the subversive Weapon X project alongside Kane, and was sent to recruit Deadpool into the program; however, their power enhancement by Weapon X began to affect her memory, and she lost track of her mission. Instead, she began seducing Deadpool, but ultimately ended their relationship over his infatuation with Siryn. Deadpool was subsequently recruited by the project to eliminate her, but after he declined she was apparently killed by their agent, Sabretooth.