At a very young age, Guy noticed his mutant powers. His skin would easily get irritated and he was always in tremendous pain. Guy was raised in foster care after his parents died in a mysterious fire.
Guy underwent extensive martials arts training and mental disciplines to try and block out the pain. Professor X was able to provide Guy with a special sensory-dampening suit. However, he remained depressed and kept a gun to play 'Russian Roulette' with.
He was recruited into X-Force, and surprisingly was quickly made the leader after the Boys R Us disaster. He resented the name of Mister Sensitive, and preferred to call himself the Orphan. Coach began to urge the others into making Guy doubt himself after Guy refused to let a young mutant named Paco Perez be dissected for study. Coach even dug up information on his parents' deaths, insinuating that Guy was responsible for the fire.
Coach ordered U-Go Girl to load Guy's gun after distracting him. Guy was easily able to tell the difference due to his senses. He and Wolverine were able to kill Smoke and Succubus, and Edie ended up shooting Coach.
Guy was forced into making the team lose to pay back money the CIA lost on Paco. On their next mission Edie was shot by the Bush Rangers, causing Guy to become even more depressed. Venus Dee Milo was selected to replace her, but Guy initially rejected her. After hearing her own tragic tale, he accepted her, and the two became lovers.
Guy had problems both with the Bad Guy posing as him, and with the Mysterious Fanboy joining the team seeking revenge for the death of U-Go Girl.
Guy stepped down as leader with his good friend Anarchist taking his place. On their last mission, which they thought would give them enough money to retire comfortably, the team was ambushed. Guy had 'a funny feeling' about the mission. Tike and Guy survived the initial attack, then ran in for one last blaze of glory. They are presumed dead.