A clone of the geneticist Mister Sinister
, Claudine Renko was sent out into the world by her creator to wait as a fail-safe in the event of his death. When that ultimately occurred, Claudine was activated. She was then recruited by mutant businessman Sebastian Shaw
to unlock the memories of Wolverine
's son Daken
; however, they faced opposition from Wolverine and Charles Xavier
. Claudine confronted Xavier but she lacked his experience and he easily defeated her. She then sought to manipulate Daken by implanting false memories of a shared life with her; however he saw through her falsehood and stabbed her in the abdomen with his claws. She fled to an unknown location where she healed from her injuries.