Collects Fantastic Four (1961) #21-29. Stan Lee and Jack Kirby set the standard for out-of-this-world imaginative adventure with the Fantastic Four! Now, with all the Marvel Universe's super-heroic players in place, it's time for the FF to run the gauntlet! The Thing throws down with the Hulk in a battle so huge it takes the combined might of the FF and the Avengers to stop it! The Sub-Mariner makes a play for Sue Storm! The FF tangle with the X-Men! Nick Fury drops by in the story that set the table for his debut as an agent of S.H.I.E.L.D.! Even Doctor Strange makes an ever-so-astral appearance! And there are villains, too - from the Mole Man and Doctor Doom to the Mad Thinker, Red Ghost and the outer-space Infant Terrible!