Zhered-Na was a sorceress in Atlantis circa 18,000 BC. Exiled by emperor Kamuu for her prophecy that Atlantis would sink, she relocated to the mainland Thurian continent where she taught about her god Valka. These lessons became the Cult of Zhered-Na. When the star-spanning Celestials caused the Great Cataclysm, sinking Atlantis, Zhered-Na was killed by a pawn of the demonic Dweller-In-Darkness, while her Cult was driven off by superstitious villagers. Zhered-Na's former apprentice, Dakimh, continued her teachings and perpetuated the Cult throughout his extended lifespan. Centuries ago, a demon and an angel shared the mystic knowledge of their realms with Cultist Illyana Kale, who added it to her own knowledge to complete the Tome of Zhered-Na. To prevent the knowledge's abuse, only the combination of a Kale and angelic and demonic agents could utilize the Tome.
Recently, Jennifer learned of the Tome via her grandfather, who led the modern incarnation of the Cult. The aged Dakimh took Jennifer as his apprentice, drawing energies from the angelic realm Therea and demonic realm Sominus to use the Tome to prevent Earth's invasion by the demon Thog. Jennifer joined Dakimh, the Man-Thing, Howard the Duck, and Korrek, warrior of extradimensional Katharta, in opposing further plots of Thog, the Congress of Realities, the wizard Klonus and barbarian Mortak, and the mad demon Bzzk'joh and his Imperium Emporium. Even after Dakimh's death, his spirit continued to advise her. Between efforts to live a normal life at various colleges, she has been drawn into numerous magical conflicts, including learning of her familial connection to both Johnny Blaze and Dan Ketch.
Recently, the demon Marduk Kurios, one of many to use the alias Satan, duped Andrew Kale into touching the Tome of Zhered-Na, unleashing the curse of the Hellphyr which threatened to destroy all magical beings on Earth. Doctor Strange recruited Jennifer, the angelic Topaz, and the demon Satana to oppose this nefarious plot, and Jennifer was ultimately forced to slay her Hellphyr-possessed brother. Afterwards, she refused to surrender her familial Tome, remaining together with Topaz and Satana as three Witches, hoping to keep the world safe from similar mystic threats.