“The Sinister Six have gotten back together. They’re some of the most powerful foes I’ve fought individually. Together, they kicked my butt all over the place,” the Wall-Crawler, his costume in tatters, told Nova in SPIDER-MAN #20. In a particularly ingenious move, Mysterio convinced Solo (no, not that one) that he was fighting the Six when Solo was, in reality, fighting Spider-Man. Peter Parker was so injured afterwards, that he needed a special eyepatch and bionic cast that temporarily turned him into a cyborg.
Eyepatches are cool, so that's a win. But ultimately this is a big L in the L-column. ("L" stands for "Loss.")
The summer of 1973 will forever live in Spider-Man infamy.
Across AMAZING SPIDER-MAN #121-122, fans were devastated to see the loss of the hero’s love, Gwen Stacy. During an epic battle with the Green Goblin atop the Brooklyn Bridge, Gwen was pushed off, before Peter threw out some quick webbing to catch her...but the whiplash ended her life. At first jubilant at his apparent “save,” Spider-Man realized too late that Stacy was gone forever. Sorry, Spidey!