When the test was over, T’Challa explained that he needed the FF’s help in order to defeat Ulysses Klaw and force him out of Wakanda. During the subsequent battle, Klaw used his sonic converter on himself to transform into a being of living sound. Despite his newfound powers, Klaw was overcome and imprisoned by the heroes.
Johnny subsequently met the original Human Torch, whose android body was revived by the Mad Thinker. The two Human Torches battled at the Thinker’s command, but the artificial Jim Hammond rebelled against his control and sacrificed his life. The FF left the original Human Torch’s body behind, and it was subsequently duplicated by Immortus before Ultron used it to create the Avenger known as Vision.
Black Bolt and the Inhumans eventually escaped from their imprisonment, just in time to lend their aid to the FF and rescue Reed from the Negative Zone. Johnny and Crystal renewed their relationship, and it brought their respective families together. When Susan became pregnant with her first child, she temporarily stepped down from the team. Crystal was the natural choice to serve as the Fantastic Four's first replacement member.
Susan’s pregnancy was not without its complications. To save his wife and unborn child, Reed led the FF into the Negative Zone to retrieve Annihilus’ Cosmic Control Rod. Reed and Susan’s son, Franklin, was successfully delivered. However, Franklin’s vast powers drew Annihilus’ attention, and he attempted to draw those abilities into his own body. Reed took the drastic step of shutting down his son’s mind to save his life, which caused a rift with his wife. In response, Susan once again left the team and took Franklin with her. Johnny’s relationship with Crystal also came to an end, as she began a romance with Quicksilver.
This time, Medusa stepped up as Susan’s replacement on the roster. The Invisible Girl eventually returned to the team, and Franklin was restored during a battle with Ultron at the wedding of Crystal and Quicksilver. The Thing briefly lost his powers and regained his human form as Ben Grimm. Luke Cage took Grimm's spot on the team until Reed provided Ben with a Thing exoskeleton that mimicked his old form and powers. During a battle with Galactus, Ben was once again transformed into the Thing. Johnny also began dating Frankie Raye, the stepdaughter of Professor Phineas T. Horton, the creator of the original Human Torch.
The Fantastic Four was once again drawn into conflict with Doctor Doom as the citizens of Latveria rose up against him. Prince Zorba of the Latverian royal family teamed up with the FF to depose Doom, and the aristocrat reclaimed the country for his people while the despot was imprisoned. Unfortunately, Zorba’s reforms were short lived and his sanity quickly eroded. The FF were put in the awkward position of teaming with Doom to retake the country from Zorba. In the end, Doom seemingly killed Zorba and expelled his enemies from Latveria as he retook control.
As her relationship with Johnny progressed, Frankie gained Human Torch-like powers of her own thanks to an accident that happened when she handled her stepfather’s chemicals as a child. Soon after, a greatly weakened Galactus attacked the Earth before he was soundly defeated by the FF and the other assembled heroes. Reed realized that Galactus was dying and attempted to save his life. Frankie offered herself to Galactus as his new herald, and she was transformed into the cosmically powered Nova. Johnny was heartbroken by Frankie’s decision and her subsequent departure from Earth.
During a battle with Galactus’ renegade herald, Terrax, Doom was seemingly killed. However, the tyrant successfully transferred his mind to an innocent bystander before he was annihilated. The FF soon discovered that Reed had been kidnapped and placed on trial for his role in saving Galactus’ life, although he managed to convince the alien court that his actions were justified. Susan became pregnant with her second child, and thus was not with the team when they were transported by the Beyonder to Battleworld for the first Secret Wars.
On Battleworld, Thing discovered that he could transform to Ben Grimm at will and decided to remain on the planet after the Secret Wars came to an end. Ben asked She-Hulk to take his place on the FF, and she returned to Earth with Reed and Johnny. Reed reunited with his wife while Johnny broke the news about Ben’s departure to Alicia. Susan’s pregnancy took a turn for the worse, and Reed attempted to recruit Doctor Octopus to save her and the baby. However, tragedy struck when Reed and Susan’s daughter was stillborn.
After various misadventures on Battleworld, the Thing returned to Earth and discovered that Johnny and Alicia were dating. Feeling betrayed, Ben decided not to return to the FF. A short time later, the Beyonder came to Earth and kicked off the second Secret Wars. At the same time, the Psycho-Man trapped Susan and Alicia before using his powers to transform the Invisible Girl into Malice, the self-proclaimed Mistress of Hate.
As Malice, Susan harshly defeated and hurt her teammates, even with Daredevil providing a much needed assist. Reed eventually goaded Susan into breaking through the brainwashing, and she sought revenge on the Psycho-Man. The team confronted the Psycho-Man and defeated him, while Susan embraced a new heroic persona as the Invisible Woman. Shortly thereafter, Doom was able to return to his own body.
The Thing returned to the team just in time for the marriage of Johnny and Alicia, as She-Hulk rejoined the Avengers. Reed and Susan decided to retire and give Franklin a more normal childhood, so they left Ben in charge of the team. Crystal once again joined the FF as her marriage with Quicksilver crumbled, and Thing also recruited the second Ms. Marvel, Sharon Ventura, to fill out the roster.
Sharon and Ben began exploring their romantic feelings for each other, but their exposure to more cosmic rays transformed her into a She-Thing while giving Ben an even more mutated appearance. Sharon’s sanity was sorely tested by the experience, and she displayed manic episodes of depression. Reed and Susan eventually returned to the team, and Thing became Ben Grimm once more while facing the Frightful Four while Sharon remained trapped as the She-Thing.
A renegade Skrull subdued the FF while impersonating Susan, and she convinced Spider-Man, Ghost Rider, Hulk, and Wolverine to form a new Fantastic Four while she pursued her own agenda. The Skrull attempted to manipulate Reed into helping her as well, but he tricked her into exposing her true agenda and freed the rest of his team. A short time later, Sharon accepted a devil’s bargain with Doctor Doom to regain her human form just as Ben purposefully transformed back into the Thing to be with Sharon.
The Puppet Master returned and exposed Alicia as a fraud. When cornered, “Alicia” confessed that she was secretly Lyja, a Skrull agent who was sent to impersonate Masters and spy on the team. Lyja claimed that her feelings for Johnny were genuine, and she helped the FF rescue the real Alicia from the Skrulls. This proved to be complicated for Ben, as he had already emotionally moved on from his relationship with Alicia. Lyja was seemingly killed during the rescue, but she was healed by Paibok the Power Skrull, her former lover.
Months later, Lyja joined Paibok on his quest for revenge against Johnny and the Fantastic Four, but she ultimately sided with her ex-husband and unofficially joined the team. Reed’s father, Nathaniel Richards, kidnapped Franklin and claimed that his powers were a threat to the world. Nathaniel successfully eluded the team and transported Franklin to the future. Moments later, Franklin returned to the present as a teenager, who called himself Psi-Lord. The FF, and Susan in particular, didn’t trust that Franklin was who he said he was. But he eventually won them over and formed his own Fantastic Force.
When the alien entity known as the Hunger invaded Latveria, the FF raced to defend its people and aid Doom in the battle. Doom seemingly suffered a fatal injury, and he took the opportunity to kill himself and Reed at the same time. Susan was devastated by Reed’s apparent death, although she refused to fully accept it. In Reed’s absence, Namor and Ant-Man unofficially joined the team, as did Kristoff Vernard, Doom’s adoptive heir.
Months later, the Fantastic Four discovered that Reed had been banished to the past by Hyperstorm, the son of Rachel Summers and Franklin Richards from an alternate timeline. Hyperstorm had also spirited away Doom and held him prisoner. The FF eventually found Reed and confronted Hyperstorm, but not before he changed Franklin’s personal timeline and once again returned him to his original age.
Reed barely had time to adjust to his return before the team was drawn into the battle against Onslaught, the malevolent psychic entity created by the fusion of Charles Xavier and Magneto’s minds. Onslaught kidnapped Franklin to use his powers, but he was defeated by the combined forces of the FF, the Avengers, and the X-Men. To prevent Onslaught from reforming, the Fantastic Four and most of the Avengers seemingly sacrificed their lives.
Thanks to the incredible powers of Franklin, his parents and their allies were not lost forever. Instead, they found themselves on an alternate Earth where they experienced a bizarre remix of their histories before discovering the truth about their fate. The Fantastic Four and the Avengers were then able to return home and resume their lives.
Much to the surprise of everyone, the FF soon encountered Valeria von Doom, a young woman who claimed to be the daughter of Susan and Doctor Doom from the future. She proved to be a valuable ally in the battle against the cosmic entity known as Abraxas. The team soon learned that Valeria was actually the daughter that Reed and Susan who had been lost years before, and she was miraculously saved by Franklin’s intervention. Somehow, the older Valeria was returned to Susan’s womb in the present. This time, she was successfully delivered thanks to the efforts of Doom himself, who named her Valeria, after his lost love.